Angebote zu "B-Cell" (7 Treffer)

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Flow Cytometric Immunophenotyping of Mature B-c...
64,90 € *
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Flow cytometer became one of the most pivotal and definitive techniques in the diagnosis and classification of mature B cell neoplasm (MBCN). Since flow cytometer exploits the laser and photomultiplier technology for reliable high quality result with extremely high sensitivity and specificity, we used these important specifications in this project to study the properties of B cells in the adult patients whose have initial diagnosis of (MBCN). This book discussed the diversity of the flow cytometer parameters (such as the percentage of positive cells, the mean fluorescence intensity and the positive peak width) which showed a remarkable role in the diagnosis of MBCN and in differentiation between CLL and NHL. The worth of the idea of this diversity of the parameters exhibited in the minimization of the markers number following into the minimization of panel cost without affecting the result. Also, using of CD20 & CD19 with their flow cytometric parameters and without the other scoring markers showed a significant role in differentiation between CLL and NHL. These ideas are appropriate for the used in laboratories of limited resources.

Anbieter: Dodax
Stand: 23.02.2020
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TGN1412
34,00 € *
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High Quality Content by WIKIPEDIA articles! High Quality Content by WIKIPEDIA articles! TGN1412 (also known as CD28-SuperMAB) is the working name of an immunomodulatory drug which was withdrawn from development. Originally intended for the treatment of B cell chronic lymphocytic leukemia (B-CLL) and rheumatoid arthritis, it is a humanised monoclonal antibody that not only binds to, but is a strong agonist for, the CD28 receptor of the immune system's T cells. In its first human clinical trials in March 2006, it caused catastrophic systemic organ failure in the subjects, despite being administered at a supposed sub-clinical dose of 0.1 mg per kg, some 500 times lower than the dose found safe in animals. Six volunteers were hospitalized on 13 March 2006, at least four of these suffering from multiple organ dysfunction, and one trial volunteer is said to show signs of developing cancer.

Anbieter: Dodax
Stand: 23.02.2020
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ZAP-70 phosphorylation and other prognostic fac...
103,00 CHF *
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This book is the culmination of a major three and half-years' work on B-chronic lymphocytic leukaemia (B-CLL) to stratify its prognostication. It represents a comprehensive analysis of various prognostic factors in adult B-CLL patients. The book is a fantastic resource and could be used by a range of professionals. Its main focus is on the laboratory diagnosis of B-CLL using basic methods as well as flow cytometry. Flow cytometry is further employed to demonstrate that ZAP-70 positive cells are more responsive to signals derived from their surounding environment, such as stromal cell-derived factor 1-alpha (SDF-1a).

Anbieter: Orell Fuessli CH
Stand: 23.02.2020
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Chronic Lymphocytic Leukemia
250,90 CHF *
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Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient. TOC:B Cell Development and Its Deregulation to Transformed States at the Pre B Cell Receptor - Expressing Pre BII Cell Stage.- Gene Expression Patterns in Human and Mouse B Cell Development.- New Insights Into the Phenotype and Cell Derivation of B-Cell Chronic Lymphocytic Leukemia.- Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models.- What Do Somatic Hypermutation and Classic Switch Recombination Teach Us About Chronic Lymphocytic Leukemia Pathogenesis.- Chronic Lymphocytic Leukemia: A Review of the Immunoarchitecture.- Clinical and Laboratory Parameters That Define B-CLL Subgroups of Clinical Relevance.- Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements.- Genotypic Prognostic Markers.- Chronic Lymphocytic Leukemia: Clinical Translations of Biological Features.- Subject Index.

Anbieter: Orell Fuessli CH
Stand: 23.02.2020
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ZAP-70 phosphorylation and other prognostic fac...
53,99 € *
ggf. zzgl. Versand

This book is the culmination of a major three and half-years' work on B-chronic lymphocytic leukaemia (B-CLL) to stratify its prognostication. It represents a comprehensive analysis of various prognostic factors in adult B-CLL patients. The book is a fantastic resource and could be used by a range of professionals. Its main focus is on the laboratory diagnosis of B-CLL using basic methods as well as flow cytometry. Flow cytometry is further employed to demonstrate that ZAP-70 positive cells are more responsive to signals derived from their surounding environment, such as stromal cell-derived factor 1-alpha (SDF-1a).

Anbieter: Thalia AT
Stand: 23.02.2020
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Chronic Lymphocytic Leukemia
220,00 € *
ggf. zzgl. Versand

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient. TOC:B Cell Development and Its Deregulation to Transformed States at the Pre B Cell Receptor - Expressing Pre BII Cell Stage.- Gene Expression Patterns in Human and Mouse B Cell Development.- New Insights Into the Phenotype and Cell Derivation of B-Cell Chronic Lymphocytic Leukemia.- Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models.- What Do Somatic Hypermutation and Classic Switch Recombination Teach Us About Chronic Lymphocytic Leukemia Pathogenesis.- Chronic Lymphocytic Leukemia: A Review of the Immunoarchitecture.- Clinical and Laboratory Parameters That Define B-CLL Subgroups of Clinical Relevance.- Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements.- Genotypic Prognostic Markers.- Chronic Lymphocytic Leukemia: Clinical Translations of Biological Features.- Subject Index.

Anbieter: Thalia AT
Stand: 23.02.2020
Zum Angebot