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Attackers, Packets, and Puzzles
69,90 € *
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We tackle the problem of securing communication in Local Area Networks (LANs) and making it resistant against Denial-of-Service (DoS) attacks. Our first contribution is the Cryptographic Link Layer (CLL) - a comprehensive security protocol that provides authentication and confidentiality between neighboring hosts from the link layer upwards. Verifying digital signatures in the handshake phase of CLL is an expensive task compared to symmetric-key operations. Thus, it may become a target for new DoS attacks. We introduce a countermeasure against DoS flooding attacks on public-key handshakes in LANs, called counter-flooding. A known approach against DoS attacks in the Internet are client puzzles. However, existing client puzzle schemes have drawbacks when being applied in LANs. We propose a novel, non-parallelizable scheme for client puzzles based on the computation of square roots modulo a prime. By introducing a secure client puzzle architecture we provide a solid basis to safely employ non-interactive client puzzles. In our final contribution, we pursue the idea of cryptographic puzzles beyond DoS protection and propose an offline submission protocol based on RSA time-lock puzzles.

Anbieter: Dodax
Stand: 21.10.2020
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Chronic Lymphocytic Leukemia: from A to Z
39,90 € *
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Chronic lymphocytic leukemia is the most common leukemia affecting mainly elderly individuals and follows an extremely variable course, with survival ranging from months to decades. Several characteristics of CLL facilitate basic and translational research including the high population prevalence, the easily obtainable malignant cells through venous phlebotomy, the asymptomatic phase in most patients that allows for longitudinal evaluation, and the relatively long disease-specific survival. Consensus guidelines for treatment of patients with CLL have been proposed by the ESMO Clinical Practice Guidelines, and recently recommended that the current use of prognostic tools for patients with newly diagnosed CLL should include staging (Rai or Binet), lymphocyte doubling time (LDT), Beta-2 microglobulin (beta2M), CD38 and ZAP-70 markers, CLL-relevant fluorescence in situ hybridization (FISH) panel, and, if available, IgVH gene mutation status.

Anbieter: Dodax
Stand: 21.10.2020
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Chronic Lymphocytic Leukemia
59,90 € *
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Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in western countries. It is characterized by the accumulation of monoclonal CD5+ B-lymphocytes in blood, bone marrow, and lymphoid organs, due to an imbalance between proliferation and cell death. It is a complex disease that remains misunderstood. This book, therefore describes globally this very common but extremely complex type of leukemia. Throughout this book the principal biological hallmarks of B-cells are compared with the principal features of CLL-leukemic B-cells. Additionally the current CLL epidemiology is indicated and the most common methods of diagnosis are discussed. Moreover, the principal prognostic factors of CLL are described, passing from a medical point of view to a biological description. The major characteristics conferring apoptotic avoidance of CLL cells and proliferation factors are detailed, such as the principal models for its in vitro and in vivo study. Finally, the leading conventional treatments and new therapeutic strategies against CLL are listed with their principal biological targets.

Anbieter: Dodax
Stand: 21.10.2020
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Married With Cancer
24,90 CHF *
zzgl. 3,50 CHF Versand

Eileen and Jimmy Newell had been married 24 years when Jimmy was diagnosed with Chronic Lymphocytic Cancer (CLL) during a routine physical exam. From the moment he called Eileen to deliver the news, she went from wife to wife/caregiver, a challenging role even with her training as a nurse. After several rounds of chemo over the course of seven years, Jimmy's cancer was declared as in remission, and things were looking up. Life was good-until Eileen was diagnosed with breast cancer ten years later, and suddenly, everything was turned on its head. Jimmy had to step into the role of caregiver, a role that life and a career in higher education had not prepared him for. In their book Married With Cancer, Eileen and Jimmy share how they coped as a couple through their cancer diagnoses and treatments, as patient and as caregiver. It hasn't been an easy journey, but they've had boundless love and laughter, some tears, and a few life lessons, which they share in this book to give hope and encouragement to their readers as they make their own journey toward survival.

Anbieter: Orell Fuessli CH
Stand: 21.10.2020
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ZAP-70 phosphorylation and other prognostic fac...
103,00 CHF *
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This book is the culmination of a major three and half-years' work on B-chronic lymphocytic leukaemia (B-CLL) to stratify its prognostication. It represents a comprehensive analysis of various prognostic factors in adult B-CLL patients. The book is a fantastic resource and could be used by a range of professionals. Its main focus is on the laboratory diagnosis of B-CLL using basic methods as well as flow cytometry. Flow cytometry is further employed to demonstrate that ZAP-70 positive cells are more responsive to signals derived from their surounding environment, such as stromal cell-derived factor 1-alpha (SDF-1a).

Anbieter: Orell Fuessli CH
Stand: 21.10.2020
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Chronic Lymphocytic Leukemia
250,90 CHF *
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Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient. TOC:B Cell Development and Its Deregulation to Transformed States at the Pre B Cell Receptor - Expressing Pre BII Cell Stage.- Gene Expression Patterns in Human and Mouse B Cell Development.- New Insights Into the Phenotype and Cell Derivation of B-Cell Chronic Lymphocytic Leukemia.- Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models.- What Do Somatic Hypermutation and Classic Switch Recombination Teach Us About Chronic Lymphocytic Leukemia Pathogenesis.- Chronic Lymphocytic Leukemia: A Review of the Immunoarchitecture.- Clinical and Laboratory Parameters That Define B-CLL Subgroups of Clinical Relevance.- Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements.- Genotypic Prognostic Markers.- Chronic Lymphocytic Leukemia: Clinical Translations of Biological Features.- Subject Index.

Anbieter: Orell Fuessli CH
Stand: 21.10.2020
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ZAP-70 phosphorylation and other prognostic fac...
53,99 € *
ggf. zzgl. Versand

This book is the culmination of a major three and half-years' work on B-chronic lymphocytic leukaemia (B-CLL) to stratify its prognostication. It represents a comprehensive analysis of various prognostic factors in adult B-CLL patients. The book is a fantastic resource and could be used by a range of professionals. Its main focus is on the laboratory diagnosis of B-CLL using basic methods as well as flow cytometry. Flow cytometry is further employed to demonstrate that ZAP-70 positive cells are more responsive to signals derived from their surounding environment, such as stromal cell-derived factor 1-alpha (SDF-1a).

Anbieter: Thalia AT
Stand: 21.10.2020
Zum Angebot
Married With Cancer
12,99 € *
zzgl. 3,00 € Versand

Eileen and Jimmy Newell had been married 24 years when Jimmy was diagnosed with Chronic Lymphocytic Cancer (CLL) during a routine physical exam. From the moment he called Eileen to deliver the news, she went from wife to wife/caregiver, a challenging role even with her training as a nurse. After several rounds of chemo over the course of seven years, Jimmy's cancer was declared as in remission, and things were looking up. Life was good-until Eileen was diagnosed with breast cancer ten years later, and suddenly, everything was turned on its head. Jimmy had to step into the role of caregiver, a role that life and a career in higher education had not prepared him for. In their book Married With Cancer, Eileen and Jimmy share how they coped as a couple through their cancer diagnoses and treatments, as patient and as caregiver. It hasn't been an easy journey, but they've had boundless love and laughter, some tears, and a few life lessons, which they share in this book to give hope and encouragement to their readers as they make their own journey toward survival.

Anbieter: Thalia AT
Stand: 21.10.2020
Zum Angebot
Chronic Lymphocytic Leukemia
220,00 € *
ggf. zzgl. Versand

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient. TOC:B Cell Development and Its Deregulation to Transformed States at the Pre B Cell Receptor - Expressing Pre BII Cell Stage.- Gene Expression Patterns in Human and Mouse B Cell Development.- New Insights Into the Phenotype and Cell Derivation of B-Cell Chronic Lymphocytic Leukemia.- Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models.- What Do Somatic Hypermutation and Classic Switch Recombination Teach Us About Chronic Lymphocytic Leukemia Pathogenesis.- Chronic Lymphocytic Leukemia: A Review of the Immunoarchitecture.- Clinical and Laboratory Parameters That Define B-CLL Subgroups of Clinical Relevance.- Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements.- Genotypic Prognostic Markers.- Chronic Lymphocytic Leukemia: Clinical Translations of Biological Features.- Subject Index.

Anbieter: Thalia AT
Stand: 21.10.2020
Zum Angebot