Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in western countries. It is characterized by the accumulation of monoclonal CD5+ B-lymphocytes in blood, bone marrow, and lymphoid organs, due to an imbalance between proliferation and cell death. It is a complex disease that remains misunderstood. This book, therefore describes globally this very common but extremely complex type of leukemia. Throughout this book the principal biological hallmarks of B-cells are compared with the principal features of CLL-leukemic B-cells. Additionally the current CLL epidemiology is indicated and the most common methods of diagnosis are discussed. Moreover, the principal prognostic factors of CLL are described, passing from a medical point of view to a biological description. The major characteristics conferring apoptotic avoidance of CLL cells and proliferation factors are detailed, such as the principal models for its in vitro and in vivo study. Finally, the leading conventional treatments and new therapeutic strategies against CLL are listed with their principal biological targets.
Leukaemia is commonly known as blood cancer with fatal characteristics. The age standardize rate of cancer in India is 60 to 90%. Epidemiology played an imperative role to understand the causes of diseases and its geographical prevalence which provides the opportunity to draft the policy and treatment strategies. In this book, an attempt is made to identify an epidemiological characteristic of leukemia patients of Gujarat state. This is the endeavor to describe the age-specific occurrence, deviation of hematological and biochemical parameter and genetic mutation of four main types of leukaemia (Chronic myeloid leukaemia CML, Chronic lymphoid leukaemia, CLL, Acute lymphoid leukaemia, ALL and Acute myeloid leukaemia, AML).