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Chronic Lymphocytic Leukemia
250,90 CHF *
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Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient. TOC:B Cell Development and Its Deregulation to Transformed States at the Pre B Cell Receptor - Expressing Pre BII Cell Stage.- Gene Expression Patterns in Human and Mouse B Cell Development.- New Insights Into the Phenotype and Cell Derivation of B-Cell Chronic Lymphocytic Leukemia.- Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models.- What Do Somatic Hypermutation and Classic Switch Recombination Teach Us About Chronic Lymphocytic Leukemia Pathogenesis.- Chronic Lymphocytic Leukemia: A Review of the Immunoarchitecture.- Clinical and Laboratory Parameters That Define B-CLL Subgroups of Clinical Relevance.- Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements.- Genotypic Prognostic Markers.- Chronic Lymphocytic Leukemia: Clinical Translations of Biological Features.- Subject Index.

Anbieter: Orell Fuessli CH
Stand: 05.12.2019
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Chronic Lymphocytic Leukemia
202,29 € *
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Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient. TOC:B Cell Development and Its Deregulation to Transformed States at the Pre B Cell Receptor - Expressing Pre BII Cell Stage.- Gene Expression Patterns in Human and Mouse B Cell Development.- New Insights Into the Phenotype and Cell Derivation of B-Cell Chronic Lymphocytic Leukemia.- Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models.- What Do Somatic Hypermutation and Classic Switch Recombination Teach Us About Chronic Lymphocytic Leukemia Pathogenesis.- Chronic Lymphocytic Leukemia: A Review of the Immunoarchitecture.- Clinical and Laboratory Parameters That Define B-CLL Subgroups of Clinical Relevance.- Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements.- Genotypic Prognostic Markers.- Chronic Lymphocytic Leukemia: Clinical Translations of Biological Features.- Subject Index.

Anbieter: Thalia AT
Stand: 05.12.2019
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ZAP-70 phosphorylation and other prognostic fac...
53,99 € *
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This book is the culmination of a major three and half-years' work on B-chronic lymphocytic leukaemia (B-CLL) to stratify its prognostication. It represents a comprehensive analysis of various prognostic factors in adult B-CLL patients. The book is a fantastic resource and could be used by a range of professionals. Its main focus is on the laboratory diagnosis of B-CLL using basic methods as well as flow cytometry. Flow cytometry is further employed to demonstrate that ZAP-70 positive cells are more responsive to signals derived from their surounding environment, such as stromal cell-derived factor 1-alpha (SDF-1a).

Anbieter: Thalia AT
Stand: 05.12.2019
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Responses of CLL cells to purine analogs with c...
21,99 € *
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Our findings demonstrate the need of ex vivo chronic lymphocytic leukemia cell (CLL) treatment before the application of drugs to select the most efficient manner of the patient's therapy. The obtained results confirm the link between the outcomes of the research done under ex vivo and in vivo conditions and underline the usefulness of ex vivo studies in the individual choice of CLL treatment. Our observations provide a base for further studies on the relationship between the in vivo clinical responses of patients and ex vivo pro-apoptotic activity, and the cytotoxicity of drugs against leukemic cells. Their validation by a study comprising a much larger group of patients is needed.

Anbieter: Thalia AT
Stand: 05.12.2019
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Married With Cancer
12,99 € *
zzgl. 3,00 € Versand

Eileen and Jimmy Newell had been married 24 years when Jimmy was diagnosed with Chronic Lymphocytic Cancer (CLL) during a routine physical exam. From the moment he called Eileen to deliver the news, she went from wife to wife/caregiver, a challenging role even with her training as a nurse. After several rounds of chemo over the course of seven years, Jimmy's cancer was declared as in remission, and things were looking up. Life was good-until Eileen was diagnosed with breast cancer ten years later, and suddenly, everything was turned on its head. Jimmy had to step into the role of caregiver, a role that life and a career in higher education had not prepared him for. In their book Married With Cancer, Eileen and Jimmy share how they coped as a couple through their cancer diagnoses and treatments, as patient and as caregiver. It hasn't been an easy journey, but they've had boundless love and laughter, some tears, and a few life lessons, which they share in this book to give hope and encouragement to their readers as they make their own journey toward survival.

Anbieter: Thalia AT
Stand: 05.12.2019
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Umbelliprenin and Chronic Lymphocytic Leukemia ...
28,90 € *
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Umbelliprenin and Chronic Lymphocytic Leukemia (CLL) Treatment ab 28.9 EURO

Anbieter: ebook.de
Stand: 05.12.2019
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Umbelliprenin and Chronic Lymphocytic Leukemia ...
28,90 € *
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Umbelliprenin and Chronic Lymphocytic Leukemia (CLL) Treatment ab 28.9 € als Taschenbuch: . Aus dem Bereich: Bücher, Wissenschaft, Medizin,

Anbieter: hugendubel
Stand: 05.12.2019
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Chronic Lymphocytic Leukemia
66,99 € *
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This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.

Anbieter: buecher
Stand: 05.12.2019
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Chronic Lymphocytic Leukemia
66,99 € *
ggf. zzgl. Versand

This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.

Anbieter: buecher
Stand: 05.12.2019
Zum Angebot