Umbelliprenin and Chronic Lymphocytic Leukemia (CLL) Treatment ab 28.99 € als Taschenbuch: . Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Our findings demonstrate the need of ex vivo chronic lymphocytic leukemia cell (CLL) treatment before the application of drugs to select the most efficient manner of the patient s therapy. The obtained results confirm the link between the outcomes of the research done under ex vivo and in vivo conditions and underline the usefulness of ex vivo studies in the individual choice of CLL treatment. Our observations provide a base for further studies on the relationship between the in vivo clinical responses of patients and ex vivo pro-apoptotic activity, and the cytotoxicity of drugs against leukemic cells. Their validation by a study comprising a much larger group of patients is needed.
High Quality Content by WIKIPEDIA articles! High Quality Content by WIKIPEDIA articles! TGN1412 (also known as CD28-SuperMAB) is the working name of an immunomodulatory drug which was withdrawn from development. Originally intended for the treatment of B cell chronic lymphocytic leukemia (B-CLL) and rheumatoid arthritis, it is a humanised monoclonal antibody that not only binds to, but is a strong agonist for, the CD28 receptor of the immune system's T cells. In its first human clinical trials in March 2006, it caused catastrophic systemic organ failure in the subjects, despite being administered at a supposed sub-clinical dose of 0.1 mg per kg, some 500 times lower than the dose found safe in animals. Six volunteers were hospitalized on 13 March 2006, at least four of these suffering from multiple organ dysfunction, and one trial volunteer is said to show signs of developing cancer.
Chronic Lymphocytic Leukemia (CLL) is the most common type of leukemia in western countries. One of the most important strategies in CLL chemotherapy is apoptosis induction in CLL cells. Over the last decades herbal medicines and their constituents attract the attentions for chemotherapy of CLL. Umbelliprenin is a sesquiterpene coumarin, that is synthesized by various Ferula species. Apoptosis induction and cytotoxicity toward cancerous cells by umbelliprenin, firstly showed in 2008. In my Ph.D thesis I studied the properties of apoptosis induction in CLL cell lines by umbelliprenin. For the first time I should that umbelliprenin could induce apoptosis in CLL cell lines time- and dose- dependently. umbelliprenin and other natural coumarins are hopeful compounds in the future of CLL chemotherapy.
Chronic lymphocytic leukemia is the most common leukemia affecting mainly elderly individuals and follows an extremely variable course, with survival ranging from months to decades. Several characteristics of CLL facilitate basic and translational research including the high population prevalence, the easily obtainable malignant cells through venous phlebotomy, the asymptomatic phase in most patients that allows for longitudinal evaluation, and the relatively long disease-specific survival. Consensus guidelines for treatment of patients with CLL have been proposed by the ESMO Clinical Practice Guidelines, and recently recommended that the current use of prognostic tools for patients with newly diagnosed CLL should include staging (Rai or Binet), lymphocyte doubling time (LDT), Beta-2 microglobulin (beta2M), CD38 and ZAP-70 markers, CLL-relevant fluorescence in situ hybridization (FISH) panel, and, if available, IgVH gene mutation status.
Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in western countries. It is characterized by the accumulation of monoclonal CD5+ B-lymphocytes in blood, bone marrow, and lymphoid organs, due to an imbalance between proliferation and cell death. It is a complex disease that remains misunderstood. This book, therefore describes globally this very common but extremely complex type of leukemia. Throughout this book the principal biological hallmarks of B-cells are compared with the principal features of CLL-leukemic B-cells. Additionally the current CLL epidemiology is indicated and the most common methods of diagnosis are discussed. Moreover, the principal prognostic factors of CLL are described, passing from a medical point of view to a biological description. The major characteristics conferring apoptotic avoidance of CLL cells and proliferation factors are detailed, such as the principal models for its in vitro and in vivo study. Finally, the leading conventional treatments and new therapeutic strategies against CLL are listed with their principal biological targets.
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply. Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings.We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia.
This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.
Eileen and Jimmy Newell had been married 24 years when Jimmy was diagnosed with Chronic Lymphocytic Cancer (CLL) during a routine physical exam. From the moment he called Eileen to deliver the news, she went from wife to wife/caregiver, a challenging role even with her training as a nurse. After several rounds of chemo over the course of seven years, Jimmy's cancer was declared as in remission, and things were looking up. Life was good-until Eileen was diagnosed with breast cancer ten years later, and suddenly, everything was turned on its head. Jimmy had to step into the role of caregiver, a role that life and a career in higher education had not prepared him for. In their book Married With Cancer, Eileen and Jimmy share how they coped as a couple through their cancer diagnoses and treatments, as patient and as caregiver. It hasn't been an easy journey, but they've had boundless love and laughter, some tears, and a few life lessons, which they share in this book to give hope and encouragement to their readers as they make their own journey toward survival.