The miscellaneous works of Oliver Goldsmith, with an account of his life and writings. Edited by Washington Irving. Vol. CLL
Erscheinungsdatum: 28.02.2018, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: La Prothe Se de Cheville Akile CLL, Autor: Laporte-M, Verlag: ED UNIVERSITAIRES EUROPEENNES, Imprint: Omn.Univ.Europ., Sprache: Französisch, Schlagworte: MEDICAL // Nursing // LITERARY CRITICISM // General // Clinical Medicine // Klinische und Innere Medizin, Rubrik: Literaturwissenschaft // Allgemeines, Lexika, Seiten: 164, Empfohlenes Alter: ab 1 Jahre // bis 17 Jahre, Reihe: Omn.Univ.Europ, Gewicht: 262 gr, Verkäufer: averdo
Erscheinungsdatum: 20.03.2019, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: L'heure de nous-mêmes a sonné, Titelzusatz: Messages à la base congolaise (et africaine), Autor: Tshiyoyo, Mufoncol, Redaktion: (Cll), Congo Lobi Lelo, Verlag: Congo Lobi Lelo, Sprache: Französisch, Schlagworte: Gesellschaft und Kultur // allgemein, Rubrik: Politikwissenschaft, Seiten: 176, Informationen: Paperback, Gewicht: 194 gr, Verkäufer: averdo
Includes topics such as: CLL - A Historical Perspective; Incidence & Epidemiology; Biology, Molecular Biology & Cytogenetics of CLL; What does the status of smatic hypermutations in IGVH genes tell us about the origin of CLL?; What does the status of ZAP-70 tell us about the biology of CLL? And, approach to initial therapy - When to start therapy?
Our findings demonstrate the need of ex vivo chronic lymphocytic leukemia cell (CLL) treatment before the application of drugs to select the most efficient manner of the patient s therapy. The obtained results confirm the link between the outcomes of the research done under ex vivo and in vivo conditions and underline the usefulness of ex vivo studies in the individual choice of CLL treatment. Our observations provide a base for further studies on the relationship between the in vivo clinical responses of patients and ex vivo pro-apoptotic activity, and the cytotoxicity of drugs against leukemic cells. Their validation by a study comprising a much larger group of patients is needed.
Leukämien sind maligne klonale Neoplasien deshämatopoetischen Systems.Traditionell unterteilt man zwischen akuten undchronischen Leukämien. Diechronischen Leukämien werden heute entsprechend ihrerBiologie entwederden niedrig malignen Lymphomen (CLL - chronischlymphatische Leukämie)oder dem myeloproliferativen Syndrom (CML - chronischmyeloische Leukämie)zugerechnet. Bei den akuten Leukämien, die imVergleich zu denchronischen Leukämien häufig einen raschen,gelegentlich foudroyantenVerlauf zeigen, kann man in der Regel nach derHerkunft der malignen Zellenzwischen der lymphatischen (ALL - akute lymphatischeLeukämie) und dermyeloischen Leukämie (AML - akute myeloischeLeukämie) unterscheiden.Die AML ist durch das ungezügelte Wachstumdifferenzierungs- und reifungsgestörtermyeloischer Vorläuferzellen charakterisiert. MitInfiltration desKnochenmarks wird das Wachstum normalerhämatopoetischer Zellen supprimiert.Unbehandelt führt die hieraus entstehende Anämie,Granulozytopenieund Thrombozytopenie mit der Folge von Infektionenund/oder hämorrhagischenDiathesen rasch zu einem lebensbedrohlichenKrankheitszustand.
Leukaemia is commonly known as blood cancer with fatal characteristics. The age standardize rate of cancer in India is 60 to 90%. Epidemiology played an imperative role to understand the causes of diseases and its geographical prevalence which provides the opportunity to draft the policy and treatment strategies. In this book, an attempt is made to identify an epidemiological characteristic of leukemia patients of Gujarat state. This is the endeavor to describe the age-specific occurrence, deviation of hematological and biochemical parameter and genetic mutation of four main types of leukaemia (Chronic myeloid leukaemia CML, Chronic lymphoid leukaemia, CLL, Acute lymphoid leukaemia, ALL and Acute myeloid leukaemia, AML).
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply. Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings.We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia.
We tackle the problem of securing communication in Local Area Networks (LANs) and making it resistant against Denial-of-Service (DoS) attacks. Our first contribution is the Cryptographic Link Layer (CLL) - a comprehensive security protocol that provides authentication and confidentiality between neighboring hosts from the link layer upwards. Verifying digital signatures in the handshake phase of CLL is an expensive task compared to symmetric-key operations. Thus, it may become a target for new DoS attacks. We introduce a countermeasure against DoS flooding attacks on public-key handshakes in LANs, called counter-flooding. A known approach against DoS attacks in the Internet are client puzzles. However, existing client puzzle schemes have drawbacks when being applied in LANs. We propose a novel, non-parallelizable scheme for client puzzles based on the computation of square roots modulo a prime. By introducing a secure client puzzle architecture we provide a solid basis to safely employ non-interactive client puzzles. In our final contribution, we pursue the idea of cryptographic puzzles beyond DoS protection and propose an offline submission protocol based on RSA time-lock puzzles.
This book is the culmination of a major three and half-years' work on B-chronic lymphocytic leukaemia (B-CLL) to stratify its prognostication. It represents a comprehensive analysis of various prognostic factors in adult B-CLL patients. The book is a fantastic resource and could be used by a range of professionals. Its main focus is on the laboratory diagnosis of B-CLL using basic methods as well as flow cytometry. Flow cytometry is further employed to demonstrate that ZAP-70 positive cells are more responsive to signals derived from their surounding environment, such as stromal cell-derived factor 1-alpha (SDF-1a).
This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.